After topical use of ketoconazole, irritation, dermatitis, or a burning sensation has occurred.Ī case of fatal aplastic anaemia was reported in a 23-year-old woman who had taken ketoconazole for 4 days for the treatment of vaginal discharge. Thrombocytopenia, paraesthe-sia, raised intracranial pressure, and photophobia have been reported rarely. Pruritus, rash, alopecia, headache, dizziness, impotence, and somnolence may also occur. Other adverse effects include allergic reactions such as urticaria and angioedema, and rare cases of anaphylax-is after the first dose have been reported. Ketoconazole interferes with steroid biosynthesis and adverse endocrine effects include gynaecomastia, oligospermia, menstrual irregularities, and adrenal cortex suppression, especially at high doses. Hepatitis has been reported and the risk appears to increase if treatment with ketoconazole is continued for longer than 2 weeks it is usually reversible on stopping ketoconazole but fatalities have occurred. Asymptomatic, transient elevations in serum concentrations of liver enzymes may occur in about 10% of patients. These adverse effects are dose-related and may be minimised by giving ketoconazole with food. Nausea and vomiting have been reported in about 3% of patients, and abdominal pain in about 1%. Gastrointestinal disturbances are the most frequently reported adverse effect after the oral use of ketoconazole. Read indications for use if you want to order Ketoconazole online Adverse Effects
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